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Mr Perricone was the first dermatologist to point out that inflammation was a primary cause of pretty much every skin problem out there from acne to wrinkles, and he's since been battling it with his range of brilliantly-formulated products. This cream is supercharged with a bevvy of ingredients to soothe and calm skin that's prematurely wrinkled, lacks radiance or is in need of smoothing. It smells a little like seaweed, but power through that and you'll never want to use anything else.